Effects of drugs on neutrophil chemotaxis

The effects of various drugs on chemotaxis of polymorphonuclear leukocytes (PMN's) in vitro have been studied. Response of rabbit PNM's in vitro to the chemotaxis was found to be suppressed by hydrocortisone succinate, chloroquine hydrochloride, cytochalasin B, colchicine and dibutyl cycli...

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Veröffentlicht in:Folia Pharmacologica Japonica 1976, Vol.72(1-2), pp.59-61
Hauptverfasser: MUKAIDE, Atsushi, KAMEYAMA, Tsutomu
Format: Artikel
Sprache:jpn
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Zusammenfassung:The effects of various drugs on chemotaxis of polymorphonuclear leukocytes (PMN's) in vitro have been studied. Response of rabbit PNM's in vitro to the chemotaxis was found to be suppressed by hydrocortisone succinate, chloroquine hydrochloride, cytochalasin B, colchicine and dibutyl cyclic AMP. On the other hand, 8-bromo-cyclic GMP enhanced the chemotaxis of PMN's.
ISSN:0015-5691
1347-8397
DOI:10.1254/fpj.72.59