Studies on the absorption, distribution, and excretion of 14C-pipethanate hydrochloride in mice

The peak of radioactivity was observed in the blood and bile 30 min after oral administration, and radioactivity was detected in most organs and tissues with the peak at 30 ?? 60 min, followed by a reduction. Fifty to sixty percent of radioactivity was excreted into the urine within 6hr, and 48 hr after drug administration, very little radioactivity remained. Excretion by expiration was as little as 0.35%. These results paralleled those from whole body autoradiography. High radioactivity was seen in the liver, kidney, lung, and salivary glands. Accumulation was not observed in organs or tissues.