Effect of 1-phenyl-1-hydroxy-n-pentane on the pancreatic secretion in the rat and in the canine

The effect of 1-phenyl-1-hydroxy-n-pentane (PHP) on the pancreatic secretion was investigated on the urethane anestheized rat and the pentobarbital anesthetized canine. In rats, the secretory volume of pancreatic juice and the output of protein in it were appearently increased by peroral and intraduodenal administration of PHP (50_??_200mg/kg), but not by perrectal administration (100mg/kg). However, these effects of PHP were not so marked in intraperitoneal (50_??_200mg/kg) or intravenous (5_??_10mg/kg) injection. While biliary secretion was considerably increased in either route of administration of PHP. PHP administerd intraduodenaly (25_??_200mg/kg) revealed the stimulatory effects of pancreatic secretion in the canine.