The protective effect of Menaquinone-4 (K2) on the bleeding death of mice caused by Cumarin

Animals were dead by hemorrhage due to large dosage of Dicumarol which is known as an anti-vitamin K substance. The protective effects of Menaquinone-4 (K2) and Phytonadione (K1) on the death of animals caused by Dicumarol were studied in mice. K2, K1 (5-10 mg/kg/day) or vehicle with Dicumarol (50 mg/kg/day) were orally given to three groups of mice for 10 days. The K2 or K1 treated groups significantly survived longer compared with the control group. K2 had statistically more potent protective effect than K1.