A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump

A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump

Gastric ulcers were produced in male Donryu rats (8-weeks-old) by subserosal injection of 20μl of 20% acetic acid. Five days later, an indomethacin (IND)-filled osmotic pump (OP) was implanted into the dorsal subcutaneous space in the rats and maintained for 2, 3 or 4 weeks. The natural healing of t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Folia Pharmacologica Japonica 1997, Vol.110(1), pp.11-17
Hauptverfasser: TANAKA, Mamoru, KATOH, Yoshinori, KAWASHIMA, Hidetoshi
Format: Artikel
Sprache:jpn
Schlagworte:
Acetates
Animals
Anti-Ulcer Agents - therapeutic use
Disease Models, Animal
Indomethacin
Infusion Pumps, Implantable
Male
Rats
Rats, Inbred Strains
Stomach Ulcer - chemically induced
Stomach Ulcer - drug therapy
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 17
container_issue 1
container_start_page 11
container_title Folia Pharmacologica Japonica
container_volume 110
creator TANAKA, Mamoru
KATOH, Yoshinori
KAWASHIMA, Hidetoshi
description Gastric ulcers were produced in male Donryu rats (8-weeks-old) by subserosal injection of 20μl of 20% acetic acid. Five days later, an indomethacin (IND)-filled osmotic pump (OP) was implanted into the dorsal subcutaneous space in the rats and maintained for 2, 3 or 4 weeks. The natural healing of the acetic acid-induced ulcers was significantly (P
doi_str_mv 10.1254/fpj.110.11
format Article
fullrecord <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1254_fpj_110_11</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>9285832</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3101-937e0038c32d0e27d3d34b5b09cadfbeb53dab55d471bab50d64e9f717481ea53</originalsourceid><addsrcrecordid>eNo9kEtrwzAQhEVpSUOaS-8FnQtOtZYU2ceQPiHQS3ssRo914uAXltOSf18ZB180u_qGgR1C7oGtIJbiKW-PKxgWuCJz4EJFCU_VNZkzBjKS6xRuydL7wjAmVazWHGZklsaJTHg8Jz8bWuMfrRqHJW1yGkSf0dED6rKo98OXttgXNkjh6Km02Hla1LTTvafmHEbXVNgfAq7pb6Fp46tm8Lenqr0jN7kuPS4vuiDfry9f2_do9_n2sd3sIsuBQZRyhYzxxPLYMYyV444LIw1LrXa5QSO500ZKJxSYMDC3FpjmCpRIALXkC_I45tqu8b7DPGu7otLdOQOWDS1loaUMhgWC-WE0tydToZusl04Cfx750fd6jxPXXTirxCEKUiHGuOmdsD3oLsOa_wOPHXqx</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>TANAKA, Mamoru ; KATOH, Yoshinori ; KAWASHIMA, Hidetoshi</creator><creatorcontrib>TANAKA, Mamoru ; KATOH, Yoshinori ; KAWASHIMA, Hidetoshi</creatorcontrib><description>Gastric ulcers were produced in male Donryu rats (8-weeks-old) by subserosal injection of 20μl of 20% acetic acid. Five days later, an indomethacin (IND)-filled osmotic pump (OP) was implanted into the dorsal subcutaneous space in the rats and maintained for 2, 3 or 4 weeks. The natural healing of the acetic acid-induced ulcers was significantly (P&lt;0.05) delayed by administration of IND via OP implanted for 4 weeks. Two, 3 and 4 weeks after OP implantation, the plasma IND level was 1.87±0.13, 2.43±0.16 and 0.74±0.26 (μg/ml), respectively, showing that a steady state IND plasma level was maintained for 3 weeks. The gastric mucosal PGE2 levels in rats with ulcers for 3 weeks after implantation of OP were significantly (P&lt;0.05) reduced by IND (IND(-):576.6±83.9 pg/mg, IND(+):355.6±34.7 pg/mg). Repeated administration of enprostil, famotidine and rabeprazole at 25 μg/kg, 100 mg/kg and 10 mg/kg (p.o., b i d), respectively, showed anti-ulcer activity. Teprenone and rebamipide had only slight anti-ulcer activity. These findings indicated that this model of delayed healing of acetic acid ulcers by IND using OP is useful for investigating the anti-ulcer activity of drugs.</description><identifier>ISSN: 0015-5691</identifier><identifier>EISSN: 1347-8397</identifier><identifier>DOI: 10.1254/fpj.110.11</identifier><identifier>PMID: 9285832</identifier><language>jpn</language><publisher>Japan: The Japanese Pharmacological Society</publisher><subject>Acetates ; Animals ; Anti-Ulcer Agents - therapeutic use ; Disease Models, Animal ; Indomethacin ; Infusion Pumps, Implantable ; Male ; Rats ; Rats, Inbred Strains ; Stomach Ulcer - chemically induced ; Stomach Ulcer - drug therapy</subject><ispartof>Folia Pharmacologica Japonica, 1997, Vol.110(1), pp.11-17</ispartof><rights>The Japanese PharmacologicalSociety</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9285832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TANAKA, Mamoru</creatorcontrib><creatorcontrib>KATOH, Yoshinori</creatorcontrib><creatorcontrib>KAWASHIMA, Hidetoshi</creatorcontrib><title>A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump</title><title>Folia Pharmacologica Japonica</title><addtitle>Nihon Yakurigaku Zasshi</addtitle><description>Gastric ulcers were produced in male Donryu rats (8-weeks-old) by subserosal injection of 20μl of 20% acetic acid. Five days later, an indomethacin (IND)-filled osmotic pump (OP) was implanted into the dorsal subcutaneous space in the rats and maintained for 2, 3 or 4 weeks. The natural healing of the acetic acid-induced ulcers was significantly (P&lt;0.05) delayed by administration of IND via OP implanted for 4 weeks. Two, 3 and 4 weeks after OP implantation, the plasma IND level was 1.87±0.13, 2.43±0.16 and 0.74±0.26 (μg/ml), respectively, showing that a steady state IND plasma level was maintained for 3 weeks. The gastric mucosal PGE2 levels in rats with ulcers for 3 weeks after implantation of OP were significantly (P&lt;0.05) reduced by IND (IND(-):576.6±83.9 pg/mg, IND(+):355.6±34.7 pg/mg). Repeated administration of enprostil, famotidine and rabeprazole at 25 μg/kg, 100 mg/kg and 10 mg/kg (p.o., b i d), respectively, showed anti-ulcer activity. Teprenone and rebamipide had only slight anti-ulcer activity. These findings indicated that this model of delayed healing of acetic acid ulcers by IND using OP is useful for investigating the anti-ulcer activity of drugs.</description><subject>Acetates</subject><subject>Animals</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Indomethacin</subject><subject>Infusion Pumps, Implantable</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Stomach Ulcer - chemically induced</subject><subject>Stomach Ulcer - drug therapy</subject><issn>0015-5691</issn><issn>1347-8397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtrwzAQhEVpSUOaS-8FnQtOtZYU2ceQPiHQS3ssRo914uAXltOSf18ZB180u_qGgR1C7oGtIJbiKW-PKxgWuCJz4EJFCU_VNZkzBjKS6xRuydL7wjAmVazWHGZklsaJTHg8Jz8bWuMfrRqHJW1yGkSf0dED6rKo98OXttgXNkjh6Km02Hla1LTTvafmHEbXVNgfAq7pb6Fp46tm8Lenqr0jN7kuPS4vuiDfry9f2_do9_n2sd3sIsuBQZRyhYzxxPLYMYyV444LIw1LrXa5QSO500ZKJxSYMDC3FpjmCpRIALXkC_I45tqu8b7DPGu7otLdOQOWDS1loaUMhgWC-WE0tydToZusl04Cfx750fd6jxPXXTirxCEKUiHGuOmdsD3oLsOa_wOPHXqx</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>TANAKA, Mamoru</creator><creator>KATOH, Yoshinori</creator><creator>KAWASHIMA, Hidetoshi</creator><general>The Japanese Pharmacological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1997</creationdate><title>A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump</title><author>TANAKA, Mamoru ; KATOH, Yoshinori ; KAWASHIMA, Hidetoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3101-937e0038c32d0e27d3d34b5b09cadfbeb53dab55d471bab50d64e9f717481ea53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1997</creationdate><topic>Acetates</topic><topic>Animals</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Indomethacin</topic><topic>Infusion Pumps, Implantable</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Stomach Ulcer - chemically induced</topic><topic>Stomach Ulcer - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TANAKA, Mamoru</creatorcontrib><creatorcontrib>KATOH, Yoshinori</creatorcontrib><creatorcontrib>KAWASHIMA, Hidetoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Folia Pharmacologica Japonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TANAKA, Mamoru</au><au>KATOH, Yoshinori</au><au>KAWASHIMA, Hidetoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump</atitle><jtitle>Folia Pharmacologica Japonica</jtitle><addtitle>Nihon Yakurigaku Zasshi</addtitle><date>1997</date><risdate>1997</risdate><volume>110</volume><issue>1</issue><spage>11</spage><epage>17</epage><pages>11-17</pages><issn>0015-5691</issn><eissn>1347-8397</eissn><abstract>Gastric ulcers were produced in male Donryu rats (8-weeks-old) by subserosal injection of 20μl of 20% acetic acid. Five days later, an indomethacin (IND)-filled osmotic pump (OP) was implanted into the dorsal subcutaneous space in the rats and maintained for 2, 3 or 4 weeks. The natural healing of the acetic acid-induced ulcers was significantly (P&lt;0.05) delayed by administration of IND via OP implanted for 4 weeks. Two, 3 and 4 weeks after OP implantation, the plasma IND level was 1.87±0.13, 2.43±0.16 and 0.74±0.26 (μg/ml), respectively, showing that a steady state IND plasma level was maintained for 3 weeks. The gastric mucosal PGE2 levels in rats with ulcers for 3 weeks after implantation of OP were significantly (P&lt;0.05) reduced by IND (IND(-):576.6±83.9 pg/mg, IND(+):355.6±34.7 pg/mg). Repeated administration of enprostil, famotidine and rabeprazole at 25 μg/kg, 100 mg/kg and 10 mg/kg (p.o., b i d), respectively, showed anti-ulcer activity. Teprenone and rebamipide had only slight anti-ulcer activity. These findings indicated that this model of delayed healing of acetic acid ulcers by IND using OP is useful for investigating the anti-ulcer activity of drugs.</abstract><cop>Japan</cop><pub>The Japanese Pharmacological Society</pub><pmid>9285832</pmid><doi>10.1254/fpj.110.11</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0015-5691
ispartof Folia Pharmacologica Japonica, 1997, Vol.110(1), pp.11-17
issn 0015-5691
1347-8397
language jpn
recordid cdi_crossref_primary_10_1254_fpj_110_11
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Acetates
Animals
Anti-Ulcer Agents - therapeutic use
Disease Models, Animal
Indomethacin
Infusion Pumps, Implantable
Male
Rats
Rats, Inbred Strains
Stomach Ulcer - chemically induced
Stomach Ulcer - drug therapy
title A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T01%3A38%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20new%20model%20of%20delayed%20healing%20of%20acetic%20acid%20ulcers%20in%20rats%20by%20indomethacin%20via%20osmotic%20pump&rft.jtitle=Folia%20Pharmacologica%20Japonica&rft.au=TANAKA,%20Mamoru&rft.date=1997&rft.volume=110&rft.issue=1&rft.spage=11&rft.epage=17&rft.pages=11-17&rft.issn=0015-5691&rft.eissn=1347-8397&rft_id=info:doi/10.1254/fpj.110.11&rft_dat=%3Cpubmed_cross%3E9285832%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/9285832&rfr_iscdi=true