A new model of delayed healing of acetic acid ulcers in rats by indomethacin via osmotic pump

Gastric ulcers were produced in male Donryu rats (8-weeks-old) by subserosal injection of 20μl of 20% acetic acid. Five days later, an indomethacin (IND)-filled osmotic pump (OP) was implanted into the dorsal subcutaneous space in the rats and maintained for 2, 3 or 4 weeks. The natural healing of t...

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Veröffentlicht in:	Folia Pharmacologica Japonica 1997, Vol.110(1), pp.11-17
Hauptverfasser:	TANAKA, Mamoru, KATOH, Yoshinori, KAWASHIMA, Hidetoshi
Format:	Artikel
Sprache:	jpn
Schlagworte:	Acetates Animals Anti-Ulcer Agents - therapeutic use Disease Models, Animal Indomethacin Infusion Pumps, Implantable Male Rats Rats, Inbred Strains Stomach Ulcer - chemically induced Stomach Ulcer - drug therapy
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Zusammenfassung:	Gastric ulcers were produced in male Donryu rats (8-weeks-old) by subserosal injection of 20μl of 20% acetic acid. Five days later, an indomethacin (IND)-filled osmotic pump (OP) was implanted into the dorsal subcutaneous space in the rats and maintained for 2, 3 or 4 weeks. The natural healing of the acetic acid-induced ulcers was significantly (P
ISSN:	0015-5691 1347-8397
DOI:	10.1254/fpj.110.11