Clarithromycin Associated With Torsades de Pointes

Clarithromycin Associated With Torsades de Pointes

Two cases of QT prolongation and torsades de pointes (TdP) are presented. The patients had been taking clarithromycin (400 mg/day) for respiratory disease. Although erythromycin is reportedly associated with TdP, this is the first report of clarithromycin associated with TdP in the absence of other...

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Veröffentlicht in:JAPANESE CIRCULATION JOURNAL 1999, Vol.63(5), pp.421-422
Hauptverfasser: Kamochi, Hideyuki, Nii, Takanobu, Eguchi, Kazuo, Mori, Tadashi, Yamamoto, Akifumi, Shimoda, Kazuya, Ibaraki, Kazuo
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Biological and medical sciences
Clarithromycin
Clarithromycin - adverse effects
Clarithromycin - therapeutic use
Drug toxicity and drugs side effects treatment
Electrocardiography
Female
Humans
Medical sciences
Pharmacology. Drug treatments
Respiratory Tract Diseases - drug therapy
Torsades de pointes
Torsades de Pointes - etiology
Torsades de Pointes - physiopathology
Toxicity: cardiovascular system
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Zusammenfassung:Two cases of QT prolongation and torsades de pointes (TdP) are presented. The patients had been taking clarithromycin (400 mg/day) for respiratory disease. Although erythromycin is reportedly associated with TdP, this is the first report of clarithromycin associated with TdP in the absence of other drugs already known to produce QT prolongation. (Jpn Circ J 1999; 63: 421 - 422)
ISSN:0047-1828
1347-4839
DOI:10.1253/jcj.63.421