Age Influence on Cardiac Enzyme Induction by Pyrogen Stimulation

Age Influence on Cardiac Enzyme Induction by Pyrogen Stimulation

A comparative study was made of the metabolism of cardiac muscle of young and adult rats after the injection of pyrogen, using as indices the activities of succinate dehydrogenase and NADH2-cytochrome C reductase. The results showed a tendency of tricarboxylic acid cycle enzyme activity in cardiac m...

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Veröffentlicht in:JAPANESE CIRCULATION JOURNAL 1969/12/30, Vol.33(10), pp.1079-1085
Hauptverfasser: MIYANISHI, MICHIHIRO, KASAHARA, MASAYUKI, FURONAKA, HIROSHI, ITO, MISAO, SEKIGUCHI, YOSHITAKA, URIUHARA, TOMOKO
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Animals
Citric Acid Cycle - drug effects
Cytochromes - metabolism
Electron Transport
Enzyme Induction
Mitochondria, Muscle - enzymology
Myocardium - enzymology
Oxidoreductases - metabolism
Pyrogens - pharmacology
Rats
Succinate Dehydrogenase - metabolism
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Zusammenfassung:A comparative study was made of the metabolism of cardiac muscle of young and adult rats after the injection of pyrogen, using as indices the activities of succinate dehydrogenase and NADH2-cytochrome C reductase. The results showed a tendency of tricarboxylic acid cycle enzyme activity in cardiac muscle of young rats to increase while, in contrast, a decrease was observed on older animals, following challenge with pyrogen.
ISSN:0047-1828
1347-4839
DOI:10.1253/jcj.33.1079