Diacylglycerol Kinase ζ Inhibits Ventricular Tachyarrhythmias in a Mouse Model of Heart Failure: Roles of Canonical Transient Receptor Potential (TRPC) Channels

Background: Diacylglycerol kinase ζ (DGKζ) inhibited atrial tachyarrhythmias in a mouse model of heart failure (HF) in our study. However, whether DGKζ prevents the HF-induced ventricular tachyarrhythmia (VT) is unknown. Methods and Results: Effects of DGKζ on VT using transgenic mice with transient cardiac expression of activated G protein αq (Gαq-TG; model of HF) were elucidated and double transgenic mice with cardiac-specific overexpression of both DGKζ and the activated Gαq (Gαq/DGKζ-TG) were used. Premature ventricular contraction (PVC) and/or VT were frequently observed in Gαq-TG mice but not in Gαq/DGKζ-TG and wild-type (WT) mice (P