Constituents of the Pericarps of Mallotus japonicus (Euphorbiaceae)

Rottlerin-like phloroglucinol derivatives isolated from the pericarps of Mallotus japonicus MUELL. ARG. (Euphorbiaceae) are reviewed. Chemical structures, cytotoxicity, antitumor and antitumor-promoting effects, antiviral activity, anti-HIV-RT activity, and inhibitory activity of activated macrophag...

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Veröffentlicht in:	YAKUGAKU ZASSHI 2003/04/01, Vol.123(4), pp.217-224
1. Verfasser:	ARISAWA, Munehisa
Format:	Artikel
Sprache:	jpn
Schlagworte:	Animals Antineoplastic Agents Antiviral Agents biological activity Carcinogens - antagonists & inhibitors Depression, Chemical Drugs, Chinese Herbal - chemistry Euphorbiaceae HIV Reverse Transcriptase - antagonists & inhibitors Humans Macrophage Activation - drug effects Mallotus japonicus Mallotus Plant - chemistry Phloroglucinol - chemistry Phloroglucinol - isolation & purification Phloroglucinol - pharmacology phloroglucinol derivatives Plant Bark - chemistry
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Beschreibung
Zusammenfassung:	Rottlerin-like phloroglucinol derivatives isolated from the pericarps of Mallotus japonicus MUELL. ARG. (Euphorbiaceae) are reviewed. Chemical structures, cytotoxicity, antitumor and antitumor-promoting effects, antiviral activity, anti-HIV-RT activity, and inhibitory activity of activated macrophages (inhibitory activities of NO, prostaglandin E2, tumor necrosis factor-α, and interleukin-6 production) of the phloroglucinol derivatives are described.
ISSN:	0031-6903 1347-5231
DOI:	10.1248/yakushi.123.217