Pharmacological Studies on Chemical Protectors against Radiation. VI. : Bioassay of Radio-protector by Change of Body Weight of X-Irradiated Mice

Examinations were made on the method of potency test for radiation protective agents, using S-(2-aminoethyl) isothiuronium bromide hydrobromide and 2-mercaptoethylamine, with decrease in body weight of mice by X-ray irradiation as an indicator. The effective method was found to be the use of ddY mal...

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Veröffentlicht in:	YAKUGAKU ZASSHI 1972/04/25, Vol.92(4), pp.437-441
Hauptverfasser:	SHINODA, MASATO, SHIMIZU, SETSUKO, TAKAGI, YOSHINARI, AKABOSHI, SANYA
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	Animals beta-Aminoethyl Isothiourea - therapeutic use Biological Assay Body Weight Male Mercaptoethylamines - therapeutic use Mice Mice, Inbred Strains Radiation Injuries, Experimental - prevention & control Radiation-Protective Agents - therapeutic use
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Zusammenfassung:	Examinations were made on the method of potency test for radiation protective agents, using S-(2-aminoethyl) isothiuronium bromide hydrobromide and 2-mercaptoethylamine, with decrease in body weight of mice by X-ray irradiation as an indicator. The effective method was found to be the use of ddY male mice as the experimental animal, with a X-ray dose of 400-600 R, and measuring variation in body weight during two weeks after irradiation, by which significant protective effect was found against body weight decrease.
ISSN:	0031-6903 1347-5231
DOI:	10.1248/yakushi1947.92.4_437