Synthetic Studies on Analgesic 5-Aminomethylsalicylic Acid
Analgesic 5-aminomethylsalicylic acid (V) was obtained by amination (Delepine reaction) of methyl 5-chloromethylsalicylate, prepared by chloromethylation (Blanc-Quelet reaction) of methyl salicylate by treating with formaldehyde and hydrogen chloride in the presence of zinc chloride. Total yield of...
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| Veröffentlicht in: | YAKUGAKU ZASSHI 1971/05/25, Vol.91(5), pp.590-593 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng ; jpn |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Analgesic 5-aminomethylsalicylic acid (V) was obtained by amination (Delepine reaction) of methyl 5-chloromethylsalicylate, prepared by chloromethylation (Blanc-Quelet reaction) of methyl salicylate by treating with formaldehyde and hydrogen chloride in the presence of zinc chloride. Total yield of V was 45% based on methyl salicylate. Similarly, chloromethylation of salicylic acid followed by amination gave V in 40% yield. |
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| ISSN: | 0031-6903 1347-5231 |
| DOI: | 10.1248/yakushi1947.91.5_590 |