Syntheses of Heterocyclic Compounds of Nitrogen. CXXII: Photosensitizing Dyes. (18)

Acetylacetamidoacetone was synthesized from glycine by the Dakin-West reaction and the acetamidoacetone obtained from it were converted to 2, 5-dimethyloxazole. Methiodide and ethiodide of the oxazole were prepared by application of methyl or ethyl iodide. Fusion of these quaternary salts with diphenyl-type formamidine and bipyridyl-type formamidine afforded the aminovinyl-type dyes. Pharmacological test was carried out on rabbit skin with 3, 5-dimethyl-2-(5-bromo-2-pyridylamino)-vlnyloxazolium iodide. The dye was administered as an ointment or injection and comparison was made with non-treated control group on burnt skin and measurement of inorganic salts in the blood, examining the changes and recovery of healthy, normal state.