Studies an Naphthalene Sulfonic Acid Derivatives. III: Naphthyiazohenzene Sulfonamide Derivatives; Syntheses and Tests for their Effects on Bacteria and Viruses

(1) Twenty-three derivatives of naphthylazobenzene sulfonamide were synthesized, 15 of which were unknown substances in literature, and their properties have been made clear. (2) Antibacterial effects of these above compounds were found inferior to that of sulfanilamide. (3) As for antiviral effects, activities approximately equal to that of naphthionic acid were recognized in p-(1-amino-4-sulfo-2-naphthylazo)-benzene sulfonamide, p-(2-amino-3, 6-disulf o-1-naphthylazo)-benzene sulfonamide, and p-(1-hydroxy-8-amino-3, 6-disulf o-2-naphthylazo)-benzene sulfonamide, among which the first compound with an amino and a sulfo radicals in the naphthalene ring, was the most active. It should also be noted that the azo derivatives with sulfanilamide as the diazo component, exerted antiviral effects, while the others with such diazo component as sulf apyridine, self athiazole, or sulf apyrimidine, showed almost none.