Studies on Naphthalene Sulfonic Acid Derivatives. I: Hydroxynaphthalene Sulfonic Acid Derivatives; Syntheses and Tests for their Effects on Bacteria and Viruses

(1) Twenty derivatives of hydroxynaphthalene sulfonic acid were synthesized, two of which were unknown substances in literature, and their properties have been made clear. (2) As the results of the examinations as to their antibacterial effects, it was found that three compounds, 1-naphthol-4-sulfonamide, 1-ethoxynaphthalene-4-sulfonamide, and N-(3-hydroxy-4-oxo-1-naphthylidene)-naphthionic acid, possessed slight effects, but the others did not exert any effect at all. (3) As to their antiviral effects, it was found that two compounds, 1, 2-naphthoquinone-4-sulfonic acid and the naphthylid-enenaphthionic acid, showed effects approximately equal to that of naphthionic acid.