Cyclosporine Level in Blood as Monitored by Areaunder-the-Curve (AUC). III. The Influence of Absorption Phase after Orally Dosing

Cyclosporine Level in Blood as Monitored by Areaunder-the-Curve (AUC). III. The Influence of Absorption Phase after Orally Dosing

The influence of the absorption phase (the time of maximum blood concentration ; Tmax) on the pharmacokinetics of cyclosporine (CYA) in the steady state after oral administration was studied in 26 renal transplant recipients. The patients were divided into three absorption phase groups with the Tmax...

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Veröffentlicht in:YAKUGAKU ZASSHI 1994/08/25, Vol.114(8), pp.589-596
Hauptverfasser: YUHKI, Yoshimitsu, TADANO, Kohji, TAKAHASHI, Yasushi, ISEKI, Ken, MIYAZAKI, Katsumi, HIRANO, Tetsuo
Format: Artikel
Sprache:eng ; jpn
Schlagworte:
AUC monitoring
cyclosporine
pharmacokinetics
renal transplantation
trough level monitoring
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Zusammenfassung:The influence of the absorption phase (the time of maximum blood concentration ; Tmax) on the pharmacokinetics of cyclosporine (CYA) in the steady state after oral administration was studied in 26 renal transplant recipients. The patients were divided into three absorption phase groups with the Tmax times as follows, group A (n=26) ; 0h Tmax
ISSN:0031-6903
1347-5231
DOI:10.1248/yakushi1947.114.8_589