Studies on the Metabolic Fate of Gomisin A (TJN-101). II. Absorption and Excretion in CCl4 Treated Rats

The absorption and excretion of gomisin A (TJN-101) in rats whose livers were injured by carbon tetrachloride (CCl4) were investigated. After intravenous administration of TJN-101 at a dose of 5 mg/kg, the terminal elimination half-life was 1.5 h in the CCl4-treated rats, which was two times that in...

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Veröffentlicht in:	YAKUGAKU ZASSHI 1991/09/25, Vol.111(9), pp.531-537
Hauptverfasser:	MATSUZAKI, Yutaka, MATSUZAKI, Tamae, ONO, Hiromasa, KOGUCHI, Sachiko, TAKEDA, Shuichi, TAKEDA, Shigefumi, FUNO, Shuji, ABURADA, Masaki, HOSOYA, Eikichi, OYAMA, Tsutomu
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	acute hepatic failure Administration, Oral Animals bile Blood Proteins - metabolism Carbon Tetrachloride Poisoning - metabolism CCl4 Cyclooctanes Dioxoles excretion feces gomisin A (TJN-101) Injections, Intravenous Lignans Male Met. B Polycyclic Compounds - administration & dosage Polycyclic Compounds - pharmacokinetics Protein Binding rat Rats Rats, Inbred Strains serum concentration urine
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Zusammenfassung:	The absorption and excretion of gomisin A (TJN-101) in rats whose livers were injured by carbon tetrachloride (CCl4) were investigated. After intravenous administration of TJN-101 at a dose of 5 mg/kg, the terminal elimination half-life was 1.5 h in the CCl4-treated rats, which was two times that in normal rats. The mean area under the blood concentration-time curve (AUC) value of TJN-101 in the CCl4-treated rats was twice that in normal rats, and this difference was significant (p
ISSN:	0031-6903 1347-5231
DOI:	10.1248/yakushi1947.111.9_531