Synthesis and Pharmacological Activities of 2, 3-Dihydro-1H-pyrazolo[1, 2-a]indazolium Derivatives (Medicinal Chemistry)

Synthesis and Pharmacological Activities of 2, 3-Dihydro-1H-pyrazolo[1, 2-a]indazolium Derivatives (Medicinal Chemistry)

2, 3-Dihydro-1H-pyrazolo[1, 2-a]indazolium halides were synthesized and their bronchodilating activities were studied. 2, 3-Dihydro-7-methyl-9-phenyl-1H-pyrazolo[1, 2-a]indazolium bromide (7m, FKK) was found to be effective in reducing the tracheal intraluminal pressure (bronchodilation).

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Veröffentlicht in:YAKUGAKU ZASSHI 1986/11/25, Vol.106(11), pp.1002-1007
Hauptverfasser: FUJIMURA, YASUO, SHIRAKI, YASUYUKI, NAWATA, YOSHIHARU, MATSUNAGA, ISAO
Format: Artikel
Sprache:eng ; jpn
Schlagworte:
2, 3-dihydro-1H-pyrazolo[1, 2-a]indazolium derivative
2, 3-dihydro-7-methyl-9-phenyl-1H-pyrazolo[1, 2-a]indazolium bromide
bronchodilation
bronchodilator
structure-activityrelationship
X-ray analysis
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Zusammenfassung:2, 3-Dihydro-1H-pyrazolo[1, 2-a]indazolium halides were synthesized and their bronchodilating activities were studied. 2, 3-Dihydro-7-methyl-9-phenyl-1H-pyrazolo[1, 2-a]indazolium bromide (7m, FKK) was found to be effective in reducing the tracheal intraluminal pressure (bronchodilation).
ISSN:0031-6903
1347-5231
DOI:10.1248/yakushi1947.106.11_1002