Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. I. Design and Synthesis of (.+-.)-N-(2-(3,4-Dichlorophenyl)-4-(spiro(isobenzofuran-1(3H),4'-piperidin)-1'-yl)butyl)-N-methylbenzamide, YM-35375, as a New Lead Compound for Novel Neurokinin Receptor Antagonists

Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. I. Design and Synthesis of (.+-.)-N-(2-(3,4-Dichlorophenyl)-4-(spiro(isobenzofuran-1(3H),4'-piperidin)-1'-yl)butyl)-N-methylbenzamide, YM-35375, as a New Lead Compound for Novel Neurokinin Receptor Antagonists

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1998, Vol.46 (2), p.351-354
Hauptverfasser: KUBOTA, Hirokazu, FUJII, Masahiro, IKEDA, Ken, TAKEUCHI, Makoto, SHIBANUMA, Tadao, ISOMURA, Yasuo
Format: Artikel
Sprache:eng
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ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.46.351