Enantioselective Synthesis of the α-Pyrone Subunit of Verrucosidin

4-Methoxyl-6-[(1S)-1-(trimethylsilyloxy)-1-methyl-2-oxobutyl]-3, 5-dimethyl-2H-pyran-2-one (4), a key α-pyrone subunit for the synthesis of verrucosidin (1), has been prepared from 6-ethyl-4-hydroxy-3, 5-dimethyl-2H-pyran-2-one (5) in an enantiomerically pure form.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1993/08/15, Vol.41(8), pp.1358-1361
Hauptverfasser:	HATAYAMA, Susumi, OCHI, Noriko, TAKANO, Seiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry enantioselective synthesis Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives mycotoxin Organic chemistry Preparations and properties Sharpless asymmetric epoxidation verrucosidin α-pyrone
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Beschreibung
Zusammenfassung:	4-Methoxyl-6-[(1S)-1-(trimethylsilyloxy)-1-methyl-2-oxobutyl]-3, 5-dimethyl-2H-pyran-2-one (4), a key α-pyrone subunit for the synthesis of verrucosidin (1), has been prepared from 6-ethyl-4-hydroxy-3, 5-dimethyl-2H-pyran-2-one (5) in an enantiomerically pure form.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.41.1358