EFFICIENT ENZYMATIC PREPARATION OF (+)- AND (-)-COREY LACTONE DERIVATIVES

EFFICIENT ENZYMATIC PREPARATION OF (+)- AND (-)-COREY LACTONE DERIVATIVES

Two pairs of Corey lactone derivatives, (+)-1, (-)-2 and (+)-3, (-)-4 have been efficiently prepared in high optical purity by enzymatic esterification and enzymatic hydrolysis catalyzed by lipases from Pseudomonas sp.

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1991/10/25, Vol.39(10), pp.2758-2760
Hauptverfasser: SUGAHARA, Tsutomu, SATOH, Ikuko, YAMADA, Osamu, TAKANO, Seiichi
Format: Artikel
Sprache:eng
Schlagworte:
Corey lactone
enzymatic hydrolysis
enzymatic transesterification
lipase AK
lipase PS
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Beschreibung
Zusammenfassung:Two pairs of Corey lactone derivatives, (+)-1, (-)-2 and (+)-3, (-)-4 have been efficiently prepared in high optical purity by enzymatic esterification and enzymatic hydrolysis catalyzed by lipases from Pseudomonas sp.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.39.2758