A One-Pot Isoquinoline Synthesis by Cyclodehydrogenation of N-Benzyl-α-alkylaminoacetals with Chlorosulfonic Acid : Formation of 3-Alkylisoquinolines
A direct preparation of fully aromatized 3-alkylisoquinolines (3e-p), was achieved by cyclodehydrogenation with chlorosulfonic acid of N-benzyl-α-alkylaminoacetals (2e-p) which were prepared by addition of Grignard reagent to N-benzyliminoacetals (1a-d).
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1987/12/25, Vol.35(12), pp.4964-4966 |
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| container_end_page | 4966 |
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| container_issue | 12 |
| container_start_page | 4964 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 35 |
| creator | KIDO, KAZUKO WATAINABE, YASUO |
| description | A direct preparation of fully aromatized 3-alkylisoquinolines (3e-p), was achieved by cyclodehydrogenation with chlorosulfonic acid of N-benzyl-α-alkylaminoacetals (2e-p) which were prepared by addition of Grignard reagent to N-benzyliminoacetals (1a-d). |
| doi_str_mv | 10.1248/cpb.35.4964 |
| format | Article |
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Pharm. Bull.</addtitle><date>1987-12-25</date><risdate>1987</risdate><volume>35</volume><issue>12</issue><spage>4964</spage><epage>4966</epage><pages>4964-4966</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>A direct preparation of fully aromatized 3-alkylisoquinolines (3e-p), was achieved by cyclodehydrogenation with chlorosulfonic acid of N-benzyl-α-alkylaminoacetals (2e-p) which were prepared by addition of Grignard reagent to N-benzyliminoacetals (1a-d).</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><doi>10.1248/cpb.35.4964</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1987/12/25, Vol.35(12), pp.4964-4966 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_crossref_primary_10_1248_cpb_35_4964 |
| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | 3-alkylisoquinoline alkyl halide benzyliminoacetal Chemistry chlorosulfonic acid Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives N- (3, 4-dimethoxybenzyl) -α-alkylaminoacetal N- (3-methoxybenzyl) -α-alkylaminoacetal N- (4-methylbenzyl) -α-alkylaminoacetal N-benzyl-α-alkylaminoacetal Organic chemistry Preparations and properties |
| title | A One-Pot Isoquinoline Synthesis by Cyclodehydrogenation of N-Benzyl-α-alkylaminoacetals with Chlorosulfonic Acid : Formation of 3-Alkylisoquinolines |
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