A One-Pot Isoquinoline Synthesis by Cyclodehydrogenation of N-Benzyl-α-alkylaminoacetals with Chlorosulfonic Acid : Formation of 3-Alkylisoquinolines

A direct preparation of fully aromatized 3-alkylisoquinolines (3e-p), was achieved by cyclodehydrogenation with chlorosulfonic acid of N-benzyl-α-alkylaminoacetals (2e-p) which were prepared by addition of Grignard reagent to N-benzyliminoacetals (1a-d).

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1987/12/25, Vol.35(12), pp.4964-4966
Hauptverfasser:	KIDO, KAZUKO, WATAINABE, YASUO
Format:	Artikel
Sprache:	eng
Schlagworte:	3-alkylisoquinoline alkyl halide benzyliminoacetal Chemistry chlorosulfonic acid Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives N- (3, 4-dimethoxybenzyl) -α-alkylaminoacetal N- (3-methoxybenzyl) -α-alkylaminoacetal N- (4-methylbenzyl) -α-alkylaminoacetal N-benzyl-α-alkylaminoacetal Organic chemistry Preparations and properties
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Beschreibung
Zusammenfassung:	A direct preparation of fully aromatized 3-alkylisoquinolines (3e-p), was achieved by cyclodehydrogenation with chlorosulfonic acid of N-benzyl-α-alkylaminoacetals (2e-p) which were prepared by addition of Grignard reagent to N-benzyliminoacetals (1a-d).
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.35.4964