Useful Syntheses of β-Amino-γ-ketobutyric Acid Derivatives from Aspartic Acid

C-Acylation of α-isocyanosuccinate having an aspartic acid skeleton, Dakin-West and Friedel-Crafts reactions with 2-oxazolin-5-oneacetate (aspartic acid azlactone) were found to be efficient methods for the preparation of various β-amino-γ-ketobutyric acid derivatives.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1986/11/25, Vol.34(11), pp.4516-4522
Hauptverfasser:	SEKI, MASAHIKO, KUBOTA, HITOSHI, MORIYA, TAMON, YAMAGISHI, MASAFUMI, NISHIMOTO, SHIGERU, MATSUMOTO, KAZUO
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Friedel-Crafts reaction Noncondensed benzenic compounds Organic chemistry Preparations and properties
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	C-Acylation of α-isocyanosuccinate having an aspartic acid skeleton, Dakin-West and Friedel-Crafts reactions with 2-oxazolin-5-oneacetate (aspartic acid azlactone) were found to be efficient methods for the preparation of various β-amino-γ-ketobutyric acid derivatives.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.34.4516