USING MICROBIAL REDUCTION TO SYNTHESIZE CARBACYCLIN

USING MICROBIAL REDUCTION TO SYNTHESIZE CARBACYCLIN

Microbial reduction of 7-methoxycarbonyl bicyclo[4. 3. 0]non-3-en-8-one ((±)-3) afforded the optically active (-)-3, which was efficiently converted by ring contraction using thallium (III) nitrate to the intermediate (11) used to synthesize carbacyclin (1).

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1986/07/25, Vol.34(7), pp.3058-3060
Hauptverfasser: Xie, Zhuo-Feng, Funakoshi, Kazuhisa, Suemune, Hiroshi, Oishi, Takeshi, Akita, Hiroyuki, Sakai, Kiyoshi
Format: Artikel
Sprache:eng
Schlagworte:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
thallium (III) nitrate
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Zusammenfassung:Microbial reduction of 7-methoxycarbonyl bicyclo[4. 3. 0]non-3-en-8-one ((±)-3) afforded the optically active (-)-3, which was efficiently converted by ring contraction using thallium (III) nitrate to the intermediate (11) used to synthesize carbacyclin (1).
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.34.3058