Stereochemistry of the Intramolecular Cyclization Products of Methyl 2-Bromo-5-(4-hydroxyphenyl) hexanoate : Synthesis of trans- and cis-1, 4-Dimethyltetralin

Stereochemistry of the Intramolecular Cyclization Products of Methyl 2-Bromo-5-(4-hydroxyphenyl) hexanoate : Synthesis of trans- and cis-1, 4-Dimethyltetralin

The stereochemistry of the spirodienones (2) obtained by the intramolecular cyclization of methyl 2-bromo-5-(4-hydroxyphenyl) hexanoate (1) was established by carbon-13 nuclear magnetic resonance spectral analysis and chemical transformation to trans- and cis-1, 4-dimethyltetralins (6).

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1984/02/25, Vol.32(2), pp.447-451
Hauptverfasser: IWATA, CHUZO, TANAKA, TETSUAKI, FUSAKA, TAKAFUMI, MAEZAKI, NAOYOSHI
Format: Artikel
Sprache:eng
Schlagworte:
base-induced isomerization
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Zusammenfassung:The stereochemistry of the spirodienones (2) obtained by the intramolecular cyclization of methyl 2-bromo-5-(4-hydroxyphenyl) hexanoate (1) was established by carbon-13 nuclear magnetic resonance spectral analysis and chemical transformation to trans- and cis-1, 4-dimethyltetralins (6).
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.32.447