Synthetic Studies on Isoprenoidquinones. II. Syntheses of Ubiquinone-10, Phylloquinone, and Menaquinone-4 by a Chain-Extending Method Utilizing Terminally Functionalized Isoprenoidhydroquinones

Physiologically active polyisoprenoidquinones, ubiquinone-10 (coenzyme Q10), phylloquinone (vitamin K1), and menaquinone-4 (vitamin K2(20)) were synthesized by a chain-extending method utilizing protected hydroquinones with the omega-hydroxyprenyl or omega-hydroxygeranyl side chain. Conditions for r...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1984/10/25, Vol.32(10), pp.3959-3967
Hauptverfasser:	MASAKI, YUKIO, HASHIMOTO, KINJI, KAJI, KENJI
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds, terpenoids, prostaglandins, steroids Chemistry Exact sciences and technology Organic chemistry Preparations and properties reductive desulfurization Terpenoids
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Zusammenfassung:	Physiologically active polyisoprenoidquinones, ubiquinone-10 (coenzyme Q10), phylloquinone (vitamin K1), and menaquinone-4 (vitamin K2(20)) were synthesized by a chain-extending method utilizing protected hydroquinones with the omega-hydroxyprenyl or omega-hydroxygeranyl side chain. Conditions for reductive desulfurization subsequent to allylic homologation were investigated.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.32.3959