SYNTHESIS OF A NEW POTENT ANTI-ULCER AND GASTRIC SECRETORY INHIBITING AGENT, (-)-cis-2, 3-DIHIDRO-3-(4-METHYLPIPERAZINYLMETHYL)-2-PHENYL-1, 5-BENZOTHIAZEPIN-4 (5H)-ONE HYDROCHLORIDE (BTM-1086), AND RELATED COMPOUNDS

SYNTHESIS OF A NEW POTENT ANTI-ULCER AND GASTRIC SECRETORY INHIBITING AGENT, (-)-cis-2, 3-DIHIDRO-3-(4-METHYLPIPERAZINYLMETHYL)-2-PHENYL-1, 5-BENZOTHIAZEPIN-4 (5H)-ONE HYDROCHLORIDE (BTM-1086), AND RELATED COMPOUNDS

(-)-cis-2, 3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1, 5-benzothiazepin-4 (5H)-one hydrochloride (BTM-1086) and its analogues, which possessed potent anti-ulcer and gastric secretory inhibiting activities, were synthesized and the structures of these compounds were established on the basis o...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1983/05/25, Vol.31(5), pp.1780-1783
Hauptverfasser: Ohno, Sachio, Izumi, Kihachiro, Mizukoshi, Kiyoshi, Kato, Kazuo, Hori, Mikio
Format: Artikel
Sprache:eng
Schlagworte:
BTM-1042
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Zusammenfassung:(-)-cis-2, 3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1, 5-benzothiazepin-4 (5H)-one hydrochloride (BTM-1086) and its analogues, which possessed potent anti-ulcer and gastric secretory inhibiting activities, were synthesized and the structures of these compounds were established on the basis of spectral and chemical evidences.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.31.1780