STRUCTURE OF β-CYCLODEXTRIN INCLUSION COMPLEX WITH NICOTINAMIDE

The crystal structure of the β-cyclodextrin-nicotinamide (1 : 1) complex hexahydrate was determined by the X-ray method. The β-cyclodextrin ring is round in shape with seven intramolecular hydrogen bonds between secondary hydroxyl groups. The nicotinamide molecule is included in the host β-cyclodextrin cavity with the pyridine moiety being located at the center of the cavity. The amido group protrudes outside from the primary hydroxyl side of β-cyclodextrin and forms hydrogen bonds with adjacent β-cyclodextrin and water molecules.