A New Synthetic Method of 3-Formylcephalosporins

Cephalosporin 3'-bromolactones (3) were prepared in good yields via silyl ethers (2) starting from readily available cephalosporin lactones (1). Treatment of 3 with dimethyl sulfoxide yielded 3-formylcephalosporins (4), a useful intermediate for the chemical modification at the C3-position of c...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1980/04/25, Vol.28(4), pp.1339-1341
Hauptverfasser:	SUGAWARA, TOHRU, MASUYA, HIROTOMO, KAWANO, YASUHIKO, MATSUO, TAISUKE, KUWADA, YUTAKA
Format:	Artikel
Sprache:	eng
Schlagworte:	separation of epimers
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Cephalosporin 3'-bromolactones (3) were prepared in good yields via silyl ethers (2) starting from readily available cephalosporin lactones (1). Treatment of 3 with dimethyl sulfoxide yielded 3-formylcephalosporins (4), a useful intermediate for the chemical modification at the C3-position of cephalosporins.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.28.1339