Synthesis of 2-Methyl-3-oxa-A-norestra-1, 5 (10)-dien-17β-ol and 2-Methyl-3-oxa-4, 19-bisnorpregna-1, 5 (10)-dien-20-one
The titled compounds were synthesized from the corresponding 10-propargyl-des-A-9 (10)-en-5-one derivatives through the 3, 5-seco-4-nor-dioxo steroids. The preparation of des-A-19-norpregn-9 (10)-ene-5, 20-dione involving the condensation of phenyl methyl sulfone or dimethyl sulfone with methyl 1β-m...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1973/02/25, Vol.21(2), pp.335-345 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The titled compounds were synthesized from the corresponding 10-propargyl-des-A-9 (10)-en-5-one derivatives through the 3, 5-seco-4-nor-dioxo steroids. The preparation of des-A-19-norpregn-9 (10)-ene-5, 20-dione involving the condensation of phenyl methyl sulfone or dimethyl sulfone with methyl 1β-methoxycarbonyl-5, 5-ethylenedioxy-7amethyl-3aα, 7aβ-hexahydroindan-4x-yl propionate is also described. |
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| ISSN: | 0009-2363 1347-5223 |
| DOI: | 10.1248/cpb.21.335 |