Studies on Cancer Chemoprevention by Traditional Folk Medicines XXIV.—Inhibitory Effect of a Coumarin Derivative, 7-Isopentenyloxycoumarin, against Tumor-Promotion

7-Isopentenyloxycoumarin (1) was isolated from Heracleum lanatum Michx. (Umbelliferae). Compound 1 inhibited phospholipid metabolism and Epstein–Barr virus activation caused by a potent tumor promoter. In an in vivo experiment, topical application of 1 suppressed skin-tumor-formation induced by 12-O...

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Veröffentlicht in:Biological & pharmaceutical bulletin 2002, Vol.25(2), pp.244-246
Hauptverfasser: Baba, Masaki, Jin, Yongri, Mizuno, Atsuo, Suzuki, Hisaya, Okada, Yoshihito, Takasuka, Nobuo, Tokuda, Harukuni, Nishino, Hoyoku, Okuyama, Toru
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Sprache:eng
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Zusammenfassung:7-Isopentenyloxycoumarin (1) was isolated from Heracleum lanatum Michx. (Umbelliferae). Compound 1 inhibited phospholipid metabolism and Epstein–Barr virus activation caused by a potent tumor promoter. In an in vivo experiment, topical application of 1 suppressed skin-tumor-formation induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene (DMBA) initiated mice. And it also suppressed ornithine decarboxylase activity stimulated by TPA on mouse skin. These results indicated that 7-isopentenyloxycoumarin is one of the effective compounds from natural resources for treating skin tumor formation.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.25.244