Inhibitory Effects of Steroidal Saponins on 12-O-Tetradecanoylphorbol-13-acetate (TPA)-Enhanced 32P-Incorporation into Phospholipids of HeLa Cells and Proliferation of Human Malignant Tumor Cells

Certain Lilium plants contain (25S)-spirost-5-ene-3β, 27-diol glycosides embracing 3-hydroxy-3-methylglutaric acid at the C-27 hydroxy position. One of their derivatives, methyl ester of (25R)-27-O-[(S)-3-hydroxy-3-methylglutaryl]-spirost-5-ene-3β, 27-diol 3-O-{O-α-L-rhamnopyranosyl-(1→2)-O-[β-D-glu...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1995/03/15, Vol.18(3), pp.467-469
Hauptverfasser:	MIMAKI, Yoshihiro, SASHIDA, Yutaka, KURODA, Minpei, NISHINO, Atsuko, SATOMI, Yoshiko, NISHINO, Hoyoku
Format:	Artikel
Sprache:	eng
Schlagworte:	3-hydroxy-3-methylglutaric acid ester Antineoplastic agents Biological and medical sciences Carbohydrate Sequence Cell Division - drug effects Chemotherapy Drug Interactions HeLa cell HeLa Cells human malignant tumor cell Humans Medical sciences Molecular Sequence Data Neoplasms - drug therapy Neoplasms - metabolism Pharmacology. Drug treatments phospholipid metabolism inhibition Phospholipids - metabolism Phosphorus - metabolism Phosphorus Radioisotopes proliferation inhibition Saponins - pharmacology steroidal saponin Stimulation, Chemical Tetradecanoylphorbol Acetate - antagonists & inhibitors Tetradecanoylphorbol Acetate - pharmacology Tumor Cells, Cultured - drug effects
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Zusammenfassung:	Certain Lilium plants contain (25S)-spirost-5-ene-3β, 27-diol glycosides embracing 3-hydroxy-3-methylglutaric acid at the C-27 hydroxy position. One of their derivatives, methyl ester of (25R)-27-O-[(S)-3-hydroxy-3-methylglutaryl]-spirost-5-ene-3β, 27-diol 3-O-{O-α-L-rhamnopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranoside} was found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32P-incorporation into the phospholipids of human cervical cancer (HeLa) cells and also to inhibit the proliferation of various kinds of human malignant tumor cells, pancreatic cancer (PANC-1), osteosarcoma (OST), human gastric cancer (HGC-27), pheochromocytoma (PC-12) and HeLa cells, in vitro.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.18.467