Synthesis of Gemcitabine Analogues as Potential Anti-tumor Agents
Gemcitabine analogue was designed to keep the anti-tumor activities but not to be the substrate of deoxycytidine deaminase. By coupling the 2-deoxy-2,2-difluoro sugar derivative with a bicyclic base, the gemcitabine analogue was synthesized, and its configuration was confirmed by 2D NMR studies.
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| Veröffentlicht in: | Chemistry letters 2006-08, Vol.35 (8), p.952-953 |
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| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Gemcitabine analogue was designed to keep the anti-tumor activities but not to be the substrate of deoxycytidine deaminase. By coupling the 2-deoxy-2,2-difluoro sugar derivative with a bicyclic base, the gemcitabine analogue was synthesized, and its configuration was confirmed by 2D NMR studies. |
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| ISSN: | 0366-7022 1348-0715 |
| DOI: | 10.1246/cl.2006.952 |