Colloidal Nanoparticles from Poly(N-isopropylacrylamide)-graft-DNA for Single Nucleotide Discrimination Based on Salt-induced Aggregation: Extension to Long Target DNA

Colloidal Nanoparticles from Poly(N-isopropylacrylamide)-graft-DNA for Single Nucleotide Discrimination Based on Salt-induced Aggregation: Extension to Long Target DNA

The DNA-linked colloidal nanoparticle was prepared through the phase transition of the amphiphilic copolymer consisting of DNA as the hydrophilic part and thermo-responsive poly(N-isopropylacrylamide) as the hydrophobic part. We have succeeded in detecting the single nucleotide difference of 39-mer...

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Veröffentlicht in:Chemistry letters 2004-12, Vol.33 (12), p.1602-1603
Hauptverfasser: Tang, Zhonglan, Takarada, Tohru, Sato, Yoshikuni, Maeda, Mizuo
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container_end_page 1603
container_issue 12
container_start_page 1602
container_title Chemistry letters
container_volume 33
creator Tang, Zhonglan
Takarada, Tohru
Sato, Yoshikuni
Maeda, Mizuo
description The DNA-linked colloidal nanoparticle was prepared through the phase transition of the amphiphilic copolymer consisting of DNA as the hydrophilic part and thermo-responsive poly(N-isopropylacrylamide) as the hydrophobic part. We have succeeded in detecting the single nucleotide difference of 39-mer target DNA by using a salt-induced aggregation of the particles.
doi_str_mv 10.1246/cl.2004.1602
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title Colloidal Nanoparticles from Poly(N-isopropylacrylamide)-graft-DNA for Single Nucleotide Discrimination Based on Salt-induced Aggregation: Extension to Long Target DNA
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