Stereoselective Preparation of α-Hydroxycarboxamide by Manganese Complex Catalyzed Hydration of α,β-Unsaturated Carboxamide with Molecular Oxygen and Phenylsilane

Aerobic oxidation with the combined use of phenylsilane and a manganese complex catalyst was successfully applied to the α,β-unsaturated carboxamide containing a C2-symmetrical chiral auxiliary to afford the corresponding α-hydroxycarboxamide in good-to-high yield with high stereoselectivity.