Stereoselective Crossed Aldol Reaction via Boron Enolate Generated from α-Iodoketones and 9-BBN-H
Boron enolates were in situ generated smoothly by treating α-iodo ketones with 9-BBN-H, and aldols were produced in highly diastereoselective manner by successive reaction with various aldehydes at low temperature.
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| Veröffentlicht in: | Chemistry letters 2002-07, Vol.31 (7), p.698-699 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Boron enolates were in situ generated smoothly by treating α-iodo ketones with 9-BBN-H, and aldols were produced in highly diastereoselective manner by successive reaction with various aldehydes at low temperature. |
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| ISSN: | 0366-7022 1348-0715 |
| DOI: | 10.1246/cl.2002.698 |