The Binary Reagent (MeO)3P/Me3SiCl and (MeO)3P/CH3CO2H in 5.0 M Lithium Perchlorate/Diethyl Ether. An Efficent Route to the Preparation of α-Hydrazinophosphonates and N-Hydroxy-α-aminophosphonates

α-Hydrazinophosphonates (N-hydroxy-α-aminophosphonates) are generated by lithium perchlorate-catalyzed three-component reaction of aldehydes, N,N-dimethylhydrazine (phenylhydroxylamine) and trimethylphosphite/trimethylsilyl chloride (acetic acid). The method utilizes cheaply available reagents and hence it is a practical and cost effective strategy, compared to other methods available in the literature.