Synthesis of α-Tertiary Amines by the Ruthenium-catalyzed Regioselective Allylic Amination of Tertiary Allylic Esters

Synthesis of α-Tertiary Amines by the Ruthenium-catalyzed Regioselective Allylic Amination of Tertiary Allylic Esters

We demonstrated a ruthenium-catalyzed regioselective allylic amination of tertiary allylic esters with various amines using [Cp*Ru(CH3CN)3][PF6]/5,5′-dimethyl-2,2′-bipyridine (5,5′-diMe-2,2′-bpy) and related ruthenium catalytic systems, and successfully obtained a diverse range of α-tertiary amines...

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Veröffentlicht in:Chemistry letters 2020-06, Vol.49 (6), p.645-647
Hauptverfasser: Mizuno, Shota, Tsuji, Hiroaki, Uozumi, Yasuhiro, Kawatsura, Motoi
Format: Artikel
Sprache:eng
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Zusammenfassung:We demonstrated a ruthenium-catalyzed regioselective allylic amination of tertiary allylic esters with various amines using [Cp*Ru(CH3CN)3][PF6]/5,5′-dimethyl-2,2′-bipyridine (5,5′-diMe-2,2′-bpy) and related ruthenium catalytic systems, and successfully obtained a diverse range of α-tertiary amines as single regioisomers. The present ruthenium catalytic system was effective for reactions with various types of amines.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.200107