First Asymmetric Photochemistry with Nucleosides and DNA: Enantiodifferentiating Z–E Photoisomerization of Cyclooctene

First Asymmetric Photochemistry with Nucleosides and DNA: Enantiodifferentiating Z–E Photoisomerization of Cyclooctene

Thymidine and uridine, as well as calf thymus DNA (ctDNA), have been shown for the first time to function as chiral photosensitizers in aqueous solution, to effect the enantiodifferentiating photoisomerization of (Z)-cyclooctene, giving the chiral (E)-isomer in enantiomeric excesses of up to 15%.

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Veröffentlicht in:Chemistry letters 2000-10, Vol.29 (10), p.1174-1175
Hauptverfasser: Wada, Takehiko, Sugahara, Norimitsu, Kawano, Mahito, Inoue, Yoshihisa
Format: Artikel
Sprache:eng
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Zusammenfassung:Thymidine and uridine, as well as calf thymus DNA (ctDNA), have been shown for the first time to function as chiral photosensitizers in aqueous solution, to effect the enantiodifferentiating photoisomerization of (Z)-cyclooctene, giving the chiral (E)-isomer in enantiomeric excesses of up to 15%.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2000.1174