Murine Neural Stem Cell (NSC) Line, MEB5-derived Decellularized Matrix as an In Vitro Extracellular Matrix Model in NSC Niche
Extracellular matrix (ECM) plays important roles in the maintenance of neural stem cell (NSC) stemness. However, it remains unclear how ECM maintains NSC stemness comprehensively. Here, ECM was formed by the adherent MEB5 culture, and a murine NSC line and formed ECM was prepared as a culture substr...
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| Veröffentlicht in: | Chemistry letters 2018-12, Vol.47 (12), p.1498-1501 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Extracellular matrix (ECM) plays important roles in the maintenance of neural stem cell (NSC) stemness. However, it remains unclear how ECM maintains NSC stemness comprehensively. Here, ECM was formed by the adherent MEB5 culture, and a murine NSC line and formed ECM was prepared as a culture substrate by decellularization. The prepared substrates can support MEB5 adhesion and growth and might influence neural differentiation. The prepared ECM model might be used as an in vitro ECM model in NSC niche. |
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| ISSN: | 0366-7022 1348-0715 |
| DOI: | 10.1246/cl.180788 |