BF3·Et2O-catalyzed One-pot Synthesis of N,N′-(2-Alkyl-1,3-diarylprop-1-ene-1,3-diyl)diacetamides through a Tandem Aldol–Double Ritter-type Reaction
An atom and step economic synthesis of multifunctional N,N′-(2-alkyl-1,3-diarylprop-1-ene-1,3-diyl)diacetamides employing a novel tandem aldol–double Ritter-type multicomponent one-pot reaction between aromatic aldehydes, enolizable ketones, and a nitrile source in the presence of 20 mol % of BF3·Et...
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Veröffentlicht in: | Chemistry letters 2014-11, Vol.43 (11), p.1731-1733 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | An atom and step economic synthesis of multifunctional N,N′-(2-alkyl-1,3-diarylprop-1-ene-1,3-diyl)diacetamides employing a novel tandem aldol–double Ritter-type multicomponent one-pot reaction between aromatic aldehydes, enolizable ketones, and a nitrile source in the presence of 20 mol % of BF3·Et2O is described. The reaction boosts operational simplicity, shortens reaction time, and has a simple work-up. |
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ISSN: | 0366-7022 1348-0715 |
DOI: | 10.1246/cl.140634 |