Electron-microscopic observations of polyoma virus-transformed mouse cells treated with specific immune serum

Transformed, non-malignant cells from a polyoma virus-induced mouse fibrosarcoma were treated with immune serum raised in isologous mice, and fresh guinea-pig serum (complement). Electron microscopy showed that reduction in cell viability in vitro was associated with damage to cell membranes. The ex...

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Veröffentlicht in:	Journal of cell science 1970-11, Vol.7 (3), p.711-718
Hauptverfasser:	Negroni, G, Tilly, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane Cell Transformation, Neoplastic Complement System Proteins Culture Techniques Embryo, Mammalian Endoplasmic Reticulum Fibrosarcoma - immunology Guinea Pigs Hemagglutination Inhibition Tests Immune Sera - pharmacology Mice Microscopy, Electron Neoplasms, Experimental - immunology Polyomavirus
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Beschreibung
Zusammenfassung:	Transformed, non-malignant cells from a polyoma virus-induced mouse fibrosarcoma were treated with immune serum raised in isologous mice, and fresh guinea-pig serum (complement). Electron microscopy showed that reduction in cell viability in vitro was associated with damage to cell membranes. The extravasated cell organelles showed only minimal changes.
ISSN:	0021-9533 1477-9137
DOI:	10.1242/jcs.7.3.711