The Efficacy of Dexmedetomidine in Patients with Noninvasive Ventilation: A Preliminary Study

Agitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect of dexmedetomidine in patients with NIV. This was a prospective clinical investigation in an intensive care unit. Dexmedetomidine was infused in 10 patients in whom NIV was difficult because of agitatio...

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Veröffentlicht in:	Anesthesia and analgesia 2008-07, Vol.107 (1), p.167-170
Hauptverfasser:	Akada, Shinji, Takeda, Shinhiro, Yoshida, Yuko, Nakazato, Keiko, Mori, Masaki, Hongo, Takashi, Tanaka, Keiji, Sakamoto, Atsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Dexmedetomidine - adverse effects Dexmedetomidine - therapeutic use Female Humans Hypnotics and Sedatives - therapeutic use Intensive Care Units Male Medical sciences Middle Aged Prospective Studies Psychomotor Agitation - prevention & control Respiration, Artificial - methods
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Zusammenfassung:	Agitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect of dexmedetomidine in patients with NIV. This was a prospective clinical investigation in an intensive care unit. Dexmedetomidine was infused in 10 patients in whom NIV was difficult because of agitation. Ramsay and Richmond Agitation-Sedation Scale scores were maintained at 2.94 +/- 0.94 and -1.23 +/- 1.30, respectively. All patients were successfully weaned from NIV, and the respiratory state was not worsened. This study shows that dexmedetomidine is an effective sedative drug for patients with NIV.
ISSN:	0003-2999 1526-7598
DOI:	10.1213/ane.0b013e3181732dc2