The Use of Lepirudin for Anticoagulation in Patients with Heparin-Induced Thrombocytopenia During Major Vascular Surgery

The Use of Lepirudin for Anticoagulation in Patients with Heparin-Induced Thrombocytopenia During Major Vascular Surgery

The method of anticoagulation in patients undergoing major vascular surgery with a history of heparin-induced thrombocytopenia (HIT) is controversial. We present two cases in which a bolus only technique using recombinant hirudin (Lepirudin or Refludan) was used successfully in patients with HIT sch...

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Veröffentlicht in:Anesthesia and analgesia 2001-02, Vol.92 (2), p.344-346
Hauptverfasser: Sun, Yang, Greilich, Philip E., O. Wilson, Steve I., Jackson, Mark R., Whitten, Charles W.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Anticoagulants - pharmacology
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Heparin - adverse effects
Hirudins - analogs & derivatives
Hirudins - pharmacology
Humans
Male
Medical sciences
Middle Aged
Partial Thromboplastin Time
Pharmacology. Drug treatments
Recombinant Proteins - pharmacology
Thrombocytopenia - chemically induced
Toxicity: blood
Vascular Surgical Procedures
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Zusammenfassung:The method of anticoagulation in patients undergoing major vascular surgery with a history of heparin-induced thrombocytopenia (HIT) is controversial. We present two cases in which a bolus only technique using recombinant hirudin (Lepirudin or Refludan) was used successfully in patients with HIT scheduled for vascular surgery.
ISSN:0003-2999
1526-7598
DOI:10.1213/00000539-200102000-00012