Analgesia, Pruritus, and Ventilation Exhibit a Dose-Response Relationship in Parturients Receiving Intrathecal Fentanyl During Labor

Analgesia, Pruritus, and Ventilation Exhibit a Dose-Response Relationship in Parturients Receiving Intrathecal Fentanyl During Labor

Several studies have characterized the 50% and 95% effective doses (ED50 and ED95, respectively) of intrathecal sufentanil for labor analgesia.Few have investigated these same criteria for the less expensive alternative, fentanyl. In addition, the ventilatory effects of intrathecal fentanyl at clini...

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Veröffentlicht in:Anesthesia and analgesia 1999-08, Vol.89 (2), p.378-383
Hauptverfasser: Herman, Norman L., Choi, Kue C., Affleck, Paul J., Calicott, Randy, Brackin, Reid, Singhal, Anu, Andreasen, Alyson, Gadalla, Farida, Fong, Jill, Gomillion, Matthew C., Hartman, Jinny K., Koff, Howard D., Lee, Sung Hee Rhim, Van Decar, Tama K.
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Sprache:eng
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Zusammenfassung:Several studies have characterized the 50% and 95% effective doses (ED50 and ED95, respectively) of intrathecal sufentanil for labor analgesia.Few have investigated these same criteria for the less expensive alternative, fentanyl. In addition, the ventilatory effects of intrathecal fentanyl at clinically relevant doses are unclear. We performed this study to establish the dose-response relationship of intrathecal fentanyl for both analgesia and ventilatory depression. Ninety parturients in active early labor (
ISSN:0003-2999
DOI:10.1213/00000539-199908000-00024