Thalidomide sensory neurotoxicity: A clinical and neurophysiologic study

The clinical and neurophysiologic data from 65 patients taking thalidomide were reviewed. Thalidomide sensory neurotoxicity was found to be cumulative dose dependent but occurs only when the total dose is relatively high (>20 g). The risk of developing sensory neuropathy is around 10% below this...

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Veröffentlicht in:	Neurology 2004-06, Vol.62 (12), p.2291-2293
Hauptverfasser:	CAVALETTI, G, BERONIO, A, PLASMATI, R, PASTORELLI, F, FRIGO, M, PIATTI, M, CARPO, M, RENI, L, GHIGLIONE, E, SCHENONE, A, BRIANI, C, ZARA, G, COCITO, D, ISOARDO, G, CIARAMITARO, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Dose-Response Relationship, Drug Female Humans Male Medical sciences Middle Aged Neurology Neurotoxicity Syndromes - diagnosis Neurotoxicity Syndromes - etiology Thalidomide - administration & dosage Thalidomide - poisoning
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Beschreibung
Zusammenfassung:	The clinical and neurophysiologic data from 65 patients taking thalidomide were reviewed. Thalidomide sensory neurotoxicity was found to be cumulative dose dependent but occurs only when the total dose is relatively high (>20 g). The risk of developing sensory neuropathy is around 10% below this threshold but increases with higher doses.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.62.12.2291