Pulse cyclophosphamide therapy in chronic inflammatory demyelinating polyneuropathy

Fifteen patients with chronic inflammatory demyelinating neuropathy (CIDP) were treated with pulse intravenous cyclophosphamide (IVCY) monthly for up to 6 months. Eleven patients reached a complete remission; only one patient worsened. Complications included nausea, vomiting, anemia, and hair loss....

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Veröffentlicht in:	Neurology 1998-12, Vol.51 (6), p.1735-1738
Hauptverfasser:	GOOD, J. L, CHEHRENAMA, M, MAYER, R. F, KOSKI, C. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Chronic Disease Cyclophosphamide - administration & dosage Demyelinating Diseases - drug therapy Female Humans Immunomodulators Immunosuppressive Agents - administration & dosage Injections, Intravenous Male Medical sciences Middle Aged Pharmacology. Drug treatments Polyneuropathies - drug therapy Pulsatile Flow
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Beschreibung
Zusammenfassung:	Fifteen patients with chronic inflammatory demyelinating neuropathy (CIDP) were treated with pulse intravenous cyclophosphamide (IVCY) monthly for up to 6 months. Eleven patients reached a complete remission; only one patient worsened. Complications included nausea, vomiting, anemia, and hair loss. This case series suggests that monthly IVCY is beneficial in the treatment of CIDP and warrants a controlled study.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.51.6.1735