Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin

ABSTRACT The ATP‐binding cassette transporter P‐glycoprotein (P‐gp) exerts a critical role in the systemic disposition of, and exposure to, lipophilic and amphipathic drugs, carcinogens, toxins and other xenobiotics. The ability of P‐gp to transfer a wide variety of structurally unrelated compounds...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2004-01, Vol.56 (1), p.123-128
Hauptverfasser:	Wang, Er-jia, Barecki-Roach, Mary, Johnson, William W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Bridged Bicyclo Compounds Flow Cytometry Genes, MDR Herb-Drug Interactions Humans Hypericum - chemistry Medical sciences Mice NIH 3T3 Cells Perylene - analogs & derivatives Perylene - pharmacology Pharmacology. Drug treatments Phloroglucinol - analogs & derivatives Terpenes - pharmacology
Online-Zugang:	Volltext
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