Blood Micronutrient and Thyroid Hormone Concentrations in the Oldest-Old
Several micronutrients are involved in thyroid hormone metabolism, but it is unclear whether their marginal deficits may contribute to the alterations in thyroid function observed in extreme aging. The relationships among blood concentrations of thyroid hormones and selenium, zinc, retinol, and α-to...
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Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2000-06, Vol.85 (6), p.2260-2265 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Several micronutrients are involved in thyroid hormone metabolism, but
it is unclear whether their marginal deficits may contribute to the
alterations in thyroid function observed in extreme aging. The
relationships among blood concentrations of thyroid hormones and
selenium, zinc, retinol, and α-tocopherol were studied in 44 healthy
Northern Italian oldest-old subjects (age range, 90–107 yr), selected
by the criteria of the SENIEUR protocol. Control groups included 44
healthy adult (age range, 20–65 yr) and 44 SENIEUR elderly (age range,
65–89 yr) subjects. Oldest-old subjects had higher TSH
(P < 0.01) and lower free T3
(FT3)/freeT4 (FT4) ratio,
zinc, and selenium serum values (P < 0.001)
than adult and elderly control subjects. No significant difference was
found for plasma retinol and α-tocopherol values. The associations
between micronutrients and thyroid hormones were evaluated by
multivariate analysis. In oldest-old subjects, plasma retinol was
negatively associated with FT4 (P =
0.019) and TSH serum levels (P = 0.040), whereas
serum zinc was positively associated with serum FT3
(P = 0.010) and FT3/FT4
ratio (P = 0.011). In younger subjects, no
significant association was found among thyroid variables and
micronutrients. In conclusion, blood levels of specific micronutrients
are associated with serum iodothyronine levels in extreme aging. |
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ISSN: | 0021-972X 1945-7197 |
DOI: | 10.1210/jcem.85.6.6627 |